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Many of these factors occur simultaneously

It's a domino effect that starts like this: The hypothalamus in the brain signals the pituitary glands, which then stimulate the adrenal glands to produce the stress hormones

[DOI] [PubMed] [Google Scholar] 186.Poursalehi H.R., Fekri M.S., Far F.S., Mandegari A., Izadi A., Mahmoodi R., Nematollahi H., Porgholamhosein F., Ghorani V., Fekri M.S

Melatonin has a pivotal role in the activation of the antioxidant system and induces changes in gene expression of several physiological mechanisms 21,29